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In contrast with mouse thymocytes, mouse ES cells comprise greater ranges of total genomic H3K4me3 and have increased H3K4me3 occupancy at the promoter of the pluripotent gene Oct4 forty six In agreement with this, international decreases in H3K4me3 ranges happen throughout retinoic acid (RA)-induced differentiation of mouse ES cells 47 In addition, there are dynamic adjustments in H3K4me3 profiles at particular units of genes during ES cell differentiation.
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