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Compared with mouse thymocytes, mouse ES cells comprise higher ranges of whole genomic H3K4me3 and have greater H3K4me3 occupancy on the promoter of the pluripotent gene Oct4 forty six In settlement with this, global decreases in H3K4me3 ranges occur throughout retinoic acid (RA)-induced differentiation of mouse ES cells 47 In addition, there are dynamic changes in H3K4me3 profiles at specific units of genes throughout ES cell differentiation.
Methylation of p53 protein by KMT7/SET7 is the first reported KMT-mediated methylation occasion on a non-histone protein 18 Since that discovery, several KMTs, as well as KDM1A, have been identified as p53 regulators that methylate or demethylate p53 protein, making p53 the most extensively studied non-histone protein undergoing lysine methylation four , thirteen , [law Firms](http://git.baige.me/lynnhelbig0620) sixteen , 18 , 162 Here we use p53 as a model to discuss the capabilities of lysine methylation of non-histone proteins.
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